A study finds associations between the intestinal virome in children and the risk of type 1 diabetes (T1D). Viruses have been considered as potential triggers for some autoimmune diseases, including T1D. Guoyan Zhao and colleagues examined the RNA and DNA intestinal virome of fecal samples, which were taken from birth through autoantibody development, from 11 children who eventually developed serum autoantibodies associated with T1D and from 11 controls. The authors found that intestinal virome diversity was higher in the controls than in the autoantibody cases. Sequences from a number of eukaryotic viruses previously associated with T1D development were not correlated with autoantibody development. Furthermore, controls were enriched in the genetic sequences associated with Circoviridae, compared with the autoantibody cases. The authors found higher bacteriophage diversity in controls than in the autoantibody cases. Moreover, the developmental trajectory of the bacteriophage community differed between the two groups over time. Further analyses identified bacteriophage sequences that were associated with the development of T1D and helped link the bacteriophage sequences with components of the bacterial microbiome. According to the authors, the findings identify links between virome changes and T1D.
Article #17-06359: “Intestinal virome changes precede autoimmunity in type I diabetes-susceptible children,” by Guoyan Zhao et al.