Hydrogels from transgenic silkworms

Researchers report the generation of transgenic silkworm larvae (Bombyx mori) with silk glands expressing the cytotoxic pierisin-1A enzyme of the cabbage butterfly (Pieris rapae); instead of normal cocoons, the larvae produce cocoons composed of glue-like sericin, which was used to create hydrogels capable of maintaining undifferentiated mouse embryonic stem cells.

Article #17-03449: “Bioengineered silkworms with butterfly cytotoxin-modified silk glands produce sericin cocoons with a utility for a new biomaterial,” by Ryosuke Otsuki et al.