Obsessive-compulsive disorder and basal ganglia

A study focused on the potential role of the neuronal glutamate transporter EAAT3, which is encoded by SLC1A1, in obsessive-compulsive disorder found that mice with drastically reduced expression of EAAT3 had reduced drug-induced repetitive behavior, which could be partially rescued by virus-mediated restoration of EAAT3 expression in the midbrain, suggesting that EAAT3 influences basal ganglia-dependent repetitive behaviors. - Read at PNAS

Article #17-01736: “OCD candidate gene SLC1A1/EAAT3 impacts basal ganglia-mediated activity and stereotypic behavior,” by Isaac Zike et al.