High-fat diet and small intestine health

A study of mice fed a high-fat diet for 30 days found that a high-fat diet alters the distribution and composition of small intestine microbiota, reduces small-intestinal defenses, and alters ileum biochemistry, resulting in physiological changes similar to cystic fibrosis; the authors found that the high-fat diet may alter PPAR-γ, a protein that regulates lipid metabolism and signaling, thereby affecting mucosal defenses, findings that provide insights into severe chronic disorders associated with a Western diet. - Read at PNAS.org

Article #16-12559: “High-fat diet modifies the PPAR-γ pathway leading to disruption of microbial and physiological ecosystem in murine small intestine,” by Julie Tomas et al.