Autophagy, axons, and spinal cord injury

A study finds that enhancing autophagy, which is the degradation of cytoplasmic constituents to maintain cellular homeostasis, stabilized microtubules by degrading the microtubule-destabilizing protein SCG10 and promoted axon growth in cultured mouse cortical neurons; treatment with the autophagy-inducing peptide Tat-beclin 1 reduced axon retraction, promoted axon regeneration, and improved the recovery of motor function in mice with spinal cord injury, suggesting that autophagy might aid axon regeneration. - Read at PNAS.org

Article #16-11282: “Autophagy induction stabilizes microtubules and promotes axon regeneration after spinal cord injury,” by Miao He et al.