Declines in spontaneous mutation rate

A study finds that the rate of cytosine deamination, a chemical change to a DNA building block that can lead to spontaneous mutations in organisms, declines precipitously with decreasing temperature, suggesting that the rate of spontaneous mutation has decreased by a factor of more than 4,000 with a corresponding increase in genetic stability as the Earth cooled from 100 °C to 25 °C during the last 4 billion years of life on Earth. - Read at PNAS.org

Article #16-07580: “Cytosine deamination and the precipitous decline of spontaneous mutation during Earth’s history,” by Charles A. Lewis Jr., Jesse Crayle, Shuntai Zhou, Ronald Swanstrom, and Richard Wolfenden.