Superstructure of inactive X chromosome

Using 3D mapping, microscopy, and genome editing, researchers find that the superstructure of the inactive X (Xi) chromosome in females is likely conserved across mammals, that superloops—massive loops in a chromosome’s structure—create a hub where multiple superloop anchor positions along the Xi agglomerate, and that deletion of the DXZ4 macrosatellite repeat can lead to the disappearance of superloops, suggesting that DXZ4 is essential for proper Xi packaging. - Read at PNAS.org

Article #16-09643: “Deletion of DXZ4 on the human inactive X chromosome alters higher-order genome architecture,” by Emily M. Darrow et al.