Limiting cardiac dysfunction after heart attacks

Researchers report that ischemic mouse hearts increased production of the cardioprotective polypepdide insulin-like growth factor-1 (IGF-1), but that the mouse mast cell protease 4 (MMCP-4) enzyme, homolog of human chymase, degraded IGF-1 and limited its cardioprotective effects in wild-type mice, whereas mice lacking the gene encoding MMCP-4 experienced reduced cardiac cell death and improved cardiac function by suppressing IGF-1 degradation, suggesting a potential link between human chymase inhibition and cardiac dysfunction after a heart attack. - Read at PNAS.org

Article #16-03127: “IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction,” by Thor Tejada et al.