Energy metabolism and depression

When treated with the epigenetic molecule acetyl-L-carnitine (LAC), stressed rats that were predisposed to depression displayed enhanced energy regulation, improved hyperinsulinemia and hyperglycemia, and reduced depression-like symptoms, and the authors identified metabolism-regulating genes expressed in a region of the hippocampus implicated in mood regulation that may be associated with predisposition to depression and LAC treatment response, according to a study. - Read at PNAS.org

Article #16-03111: “Epigenetics and energetics in ventral hippocampus mediate rapid antidepressant action: Implications for treatment resistance,” by B. Bigio et al.