Detecting tissue-specific cell death

In a series of experiments involving plasma samples from more than 200 patients and controls, researchers developed a diagnostic platform that identifies tissue-specific cell death based on methylation signatures of circulating DNA from dying cells, and used the tissue-specific methylation markers to detect type-1 diabetes, pancreatic cancer, pancreatitis, brain injury, cardiac arrest, or relapsing multiple sclerosis. - See at PNAS.org

Article #15-19286: “Identification of tissue-specific cell death using methylation patterns of circulating DNA,” by Roni Lehmann-Werman et al.