Genetics, brain networks, and schizophrenia

Neuroimaging and pharmacological studies of 28 schizophrenia patients, 37 unaffected relatives, and 176 healthy controls revealed that brain network flexibility during a working memory task was low in controls, intermediate in healthy relatives, and high in schizophrenia patients as well as healthy controls administered an antagonist for the glutamatergic NMDA receptor, suggesting the presence of a dynamic brain network phenotype related to genetic risk for schizophrenia that is regulated by NMDA receptor functioning. - Read at PNAS.org

Dynamic brain network reconfiguration as a potential schizophrenia genetic risk mechanism modulated by NMDA receptor function,” by Urs Braun et al.